Biofilm is any group of microorganisms in
which cells stick to each other on a surface. Biofilms may form on living or
non-living surfaces and can be prevalent in natural, industrial and hospital
settings. Biofilms have been found to be involved in a wide variety of
microbial infections in the body, by one estimate 80% of all infections.
Infectious processes in which biofilms have been implicated include common
problems such as urinary tract infections, catheter infections, middle-ear
infections, formation of dental plaque, gingivitis, coating contact lenses, and
less common but more lethal processes such as endocarditis, infections in
cystic fibrosis, and infections of permanent indwelling devices such as joint
prostheses and heart valves.
Biofilm has a stubborn resistance to conventional
sterilization, clean ,removal mechanisms, iust like spores.It often intimately
adhere to reusable medical device surface and difficult to remove.Thus,the
bacteria wrapped was protected well.There is a doubt,whether these b
microorganisms will die?The death rate?
A
mathematical treatment for analyzing biofilm for a square law of microbial
death rate is put forward in a paper published in Natural Science. The nonlinear
differential Equations in biofilm reaction is solved using the Adomian
decomposition method. Approximate analytical expressions for substrate
concentration have been derived for all values of parameters δ and SL. These
analytical results are compared with the available numerical results and are
found to be in good agreement.
(source: Scientific Research Publishing)
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